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The FDA recommends patient counseling about appropriately using aspirin and ibuprofen together. Use of the two products together may reduce the effectiveness of aspirin taken for cardioprotection and stroke prevention. Studies show that when ibuprofen and aspirin are taken concurrently, “ibuprofen interferes with the antiplatelet activity of low dose aspirin (81mg, immediate release) …” To avoid this problem, the ibuprofen should be taken at least 30 minutes after the aspirin, or at least 8 hours before the aspirin. In addition to ibuprofen, some evidence suggests that higher than non-prescription doses of naproxen taken together with aspirin may also interfere with the aspirin’s antiplatelet activity. However, acetaminophen does not appear to have the same effect.

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