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Though nephrogenic systemic fibrosis is primarily a skin disorder, it may affect other organs. The disease affects people with renal insufficiency. NSF can be diagnosis with clinical findings and tissue diagnosis. Originally the disease was termed nephrogenic fibrosing dermopathy because it was thought to be largely focused on the skin. However, the name was later changed to nephrogenic systemic fibrosis to reflect the involvement of other organs and systems of the body. Reduction in the range of motion of the joints can develop from the skin tightening and joint contractures. Some patients with nephrogenic systemic fibrosis may become severely disabled. This condition has been linked to gadolinium based contrast agents used in MRI studies.

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